解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Pterocarpans, a family of isoflavonoids found in the diverse Fabaceae, display potent cytotoxic activity over a panel of tumor cell lines, and among those tested, 2,3,9- trimethoxypterocarpan displays the most potent activity. This study evaluates the effects of 2,3,9-trimethoxypterocarpan and its related derivatives ...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2014.06.005
更新日期:2014-09-01 00:00:00
abstract::In the present study we have investigated the thermal stability of the globular transport protein human serum albumin (HSA), in the presence of two small chain polyethylene glycols (namely PEG 200 and PEG 400). Both near- and far-UV circular dichroism (CD) study reveal that addition of PEG moderately increases the α-h...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2014.05.009
更新日期:2014-09-01 00:00:00
abstract::Information on the subcellular localization of bacterial proteins is essential for protein function prediction, genome annotation and drug design. Here we proposed a novel approach to predict the subcellular localization of bacterial proteins by fusing features from position-specific score matrix (PSSM), Gene Ontology...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2014.06.001
更新日期:2014-09-01 00:00:00
abstract::Pulmonary fibrosis (PF) is a progressive lethal disorder. In this study, the effect of daidzein, a soyisoflavone against Bleomycin (BLM) induced PF in rats was elucidated. A single intratracheal instillation of BLM (3 U/kg.bw) was administered in rats to induce PF. Daidzein (0.2 mg/kg) was administered subcutaneously,...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2014.04.005
更新日期:2014-08-01 00:00:00
abstract::Glutathione, being a major intracellular redox regulator has been shown to be implicated in regulation of airway reactivity and inflammation. However, no study so far has investigated the effect of glutathione depletion/repletion during sensitization and challenge phases separately, which could provide an important in...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2014.04.001
更新日期:2014-08-01 00:00:00
abstract::Lipolytic activities of Yarrowia lipolytica LIP2 lipase (YLLIP2), human pancreatic (HPL) and dog gastric (DGL) lipases were first compared using lecithin-stabilized triacylglycerol (TAG) emulsions (Intralipid) at various pH and bile salt concentrations. Like DGL, YLLIP2 was able to hydrolyze TAG droplets covered by a ...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2014.03.004
更新日期:2014-07-01 00:00:00
abstract::MicroRNAs (miRNAs) play profound roles in plant growth and development by regulating gene expression. Tetraploid plants often have better physical characteristics and stress tolerance than their diploid progenitors, but the role of miRNAs in this superiority is unclear. Paulownia tomentosa, (Paulowniaceae) is attracti...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2014.02.008
更新日期:2014-07-01 00:00:00
abstract::Insect prophenoloxidase (PPO) is an essential innate immunity protein to induce pathogen into melanization. In Bombyx mori, pro-phenoloxidase-activating enzyme (PPAE) can directly cleave and activate PPO. However, PPO in Manduca sexta cannot be cleaved into active phenoloxidase (PO) by serine proteases unless cofactor...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2014.03.007
更新日期:2014-07-01 00:00:00
abstract::MicroRNAs (miRNAs) are ∼21 nt non-coding small RNAs which regulate gene expression at the post-transcriptional level in plants and animals. Until recently, only limited numbers of miRNAs were identified in Cucurbitaceae, a large flowering plant family. In this study, 220 potential miRNA candidates were identified from...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2014.03.002
更新日期:2014-07-01 00:00:00
abstract::Plant vacuolar invertases, which belong to family 32 of glycoside hydrolases (GH32), are key enzymes in sugar metabolism. They hydrolyse sucrose into glucose and fructose. The cDNA encoding a vacuolar invertase from Solanum lycopersicum (TIV-1) was cloned and heterologously expressed in Pichia pastoris. The functional...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2013.12.013
更新日期:2014-06-01 00:00:00
abstract::The mitochondria have arisen as a consequence of endosymbiosis of an ancestral α-proteobacterium with a methane-producing archae. The main function of the canonical aerobic mitochondria include ATP generation via oxidative phosphorylation, heme and phospholipid synthesis, calcium homeostasis, programmed cell death, an...
journal_title:Biochimie
pub_type: 杂志文章,评审
doi:10.1016/j.biochi.2013.11.018
更新日期:2014-05-01 00:00:00
abstract::Human mitochondrial diseases, defined as the diseases due to a mitochondrial oxidative phosphorylation defect, represent a large group of very diverse diseases with respect to phenotype and genetic causes. They present with many unsolved issues, the comprehensive analysis of which is beyond the scope of this review. W...
journal_title:Biochimie
pub_type: 杂志文章,评审
doi:10.1016/j.biochi.2013.08.012
更新日期:2014-05-01 00:00:00
abstract::Due to their function as adapters in translation, tRNA molecules share a common structural organization in all kingdoms and organelles with ribosomal protein biosynthesis. A typical tRNA has a cloverleaf-like secondary structure, consisting of acceptor stem, D-arm, anticodon arm, a variable region, and T-arm, with an ...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2013.07.034
更新日期:2014-05-01 00:00:00
abstract::Oxidative stress, characterized by the accumulation of reactive oxygen species (ROS), is known to have numerous detrimental effects on the myocardium such as the induction of apoptotic cell death, hypertrophy, fibrosis, dysfunction, and dilatation. Over the past several years, we have shown that mitochondrial NADP(+)-...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2013.11.016
更新日期:2014-04-01 00:00:00
abstract::Recent work has shown that a DBF4 analog in yeast may be a target of nitrogen-containing bisphosphonates. DBF4 is an essential protein kinase required for DNA replication from primary eukaryotes to humans and appears to play a critical role in the S-phase checkpoint. It is also required for cell migration and cell sur...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2013.11.010
更新日期:2014-04-01 00:00:00
abstract::Peroxisomes are subcellular organelles which are present in virtually every eukaryotic cell and catalyze a large number of metabolic functions. The importance of peroxisomes for humans is stressed by the existence of a large group of genetic diseases in which either the biogenesis of peroxisomes is impaired or one of ...
journal_title:Biochimie
pub_type: 杂志文章,评审
doi:10.1016/j.biochi.2013.08.022
更新日期:2014-03-01 00:00:00
abstract::Carbonic anhydrases (CAs, EC 4.2.1.1) are metalloenzymes found throughout the phylogenetic tree. The β-class carbonic anhydrases (β-CAs) are the predominating class of CAs in plants. Growing evidence underscores the importance of β-CAs in plant immunity and environmental adaptation in addition to their roles in photos...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2013.10.020
更新日期:2014-02-01 00:00:00
abstract::Long-term treatment with ambroxol (ABX), a bronchial expectorant, was found to prevent acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The underlying mechanism remains unclear. To address this, we have investigated the effect of ABX on critical antioxidant proteins thioredoxin (Trx) and thioredox...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2013.09.024
更新日期:2014-02-01 00:00:00
abstract::Autotaxin (ATX) is a secreted lysophospholipase D involved in synthesis of lysophosphatidic acid (LPA), a phospholipid growth factor acting via specific receptors (LPA1R to LPA6R) and involved in several pathologies including obesity. ATX is secreted by adipocytes and contributes to circulating LPA. ATX expression is ...
journal_title:Biochimie
pub_type: 杂志文章,评审
doi:10.1016/j.biochi.2013.04.010
更新日期:2014-01-01 00:00:00
abstract::Mesenchymal stem cells (MSC) show great promise in a wide array of therapeutic applications due mainly to their capacity to suppress immune and inflammatory reactions and instigate normal tissue repair processes. The secretion of bioactive factors is thought to play a predominant role in the mechanisms of action for t...
journal_title:Biochimie
pub_type: 杂志文章,评审
doi:10.1016/j.biochi.2013.06.017
更新日期:2013-12-01 00:00:00
abstract::In this study, peptidomics and genomics analyses were used to study antimicrobial peptides from the skin of Hylarana spinulosa. Twenty-nine different antimicrobial peptide precursors were characterized from the skin of H. spinulosa, which produce 23 mature antimicrobial peptides belonging to 12 different families. To ...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2013.09.002
更新日期:2013-12-01 00:00:00
abstract::We have produced and purified an active site mutant of the Escherichia coli cyclopropane fatty acid synthase (CFAS) by replacing the strictly conserved G236 within cyclopropane synthases, by a glutamate residue, which corresponds to E146 of the homologous mycolic acid methyltransferase, Hma, producing hydroxymethyl my...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2013.08.007
更新日期:2013-12-01 00:00:00
abstract::Over the last decades, mesenchymal stem cells (MSCs) have been extensively studied with regard to their potential applications in regenerative medicine. In rheumatic diseases, MSC-based therapy is the subject of great expectations for patients who are refractory to proposed treatments such as rheumatoid arthritis (RA)...
journal_title:Biochimie
pub_type: 杂志文章,评审
doi:10.1016/j.biochi.2013.04.017
更新日期:2013-12-01 00:00:00
abstract::In search for yet uncharacterized proteins involved in lipid metabolism of the chicken, we have isolated a hitherto unknown protein from the serum lipoprotein fraction with a buoyant density of ≤1.063 g/ml. Data obtained by protein microsequencing and molecular cloning of cDNA defined a 537 bp cDNA encoding a precurso...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2013.09.005
更新日期:2013-12-01 00:00:00
abstract::Matrix metalloproteinase 9 (MMP-9) and interleukin-8 (IL-8) play major roles in tumor progression and invasion of breast cancer cells. The present study was undertaken to investigate the inhibitory mechanism of cell invasion by luteolin 8-C-β-fucopyranoside (named as LU8C-FP), a C-glycosylflavone, in human breast canc...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2013.07.021
更新日期:2013-11-01 00:00:00
abstract::In septic shock patients, alterations of plasma phospholipid fatty acid profile have never been described. The purpose of this monocentric, non-interventional, observational prospective study was to describe this fatty acid profile in the early phase of septic shock in intensive care unit. Thirty-seven adult patients ...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2013.08.006
更新日期:2013-11-01 00:00:00
abstract::Plant sucrose transporters (SUTs) are functional as sucrose-proton-cotransporters with an optimal transport activity in the acidic pH range. Recently, the pH optimum of the Solanum tuberosum sucrose transporter StSUT1 was experimentally determined to range at an unexpectedly low pH of 3 or even below. Various research...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2013.07.028
更新日期:2013-11-01 00:00:00
abstract::Haloalkane dehalogenases are known as bacterial enzymes cleaving a carbon-halogen bond in halogenated compounds. Here we report the first biochemically characterized non-microbial haloalkane dehalogenase DspA from Strongylocentrotus purpuratus. The enzyme shows a preference for terminally brominated hydrocarbons and e...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2013.07.025
更新日期:2013-11-01 00:00:00
abstract::Several inositol isomers and in particular myo-inositol (MI) and D-chiro-inositol (DCI), were shown to possess insulin-mimetic properties and to be efficient in lowering post-prandial blood glucose. In addition, abnormalities in inositol metabolism are associated with insulin resistance and with long term microvascula...
journal_title:Biochimie
pub_type: 杂志文章,评审
doi:10.1016/j.biochi.2013.05.011
更新日期:2013-10-01 00:00:00
abstract::Fanconi anemia (FA) is a rare and complex inherited blood disorder of the child. At least 15 genes are associated with the disease. The highest frequency of mutations belongs to groups A, C and G. Genetic instability and cytokine hypersensitivity support the selection of leukemic over non-leukemic stem cells. FA cellu...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2013.06.006
更新日期:2013-10-01 00:00:00
abstract::Epidemiological studies have demonstrated that the diabetes mellitus is a serious health burden for both governments and healthcare providers. The present study was hypothesized to evaluate the antihyperglycemic potential of fraxetin by determining the activities of key enzymes of carbohydrate metabolism in streptozot...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2013.06.013
更新日期:2013-10-01 00:00:00
abstract::Here we report two novel 17-mer amidated linear peptides (TsAP-1 and TsAP-2) whose structures were deduced from cDNAs cloned from a venom-derived cDNA library of the Brazilian yellow scorpion, Tityus serrulatus. Both mature peptides were structurally-characterised following their location in chromatographic fractions ...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2013.06.003
更新日期:2013-09-01 00:00:00
abstract::Some physico-chemical properties of R140G and K141Q mutants of human small heat shock protein HspB1 associated with hereditary peripheral neuropathy were analyzed. Mutation K141Q did not affect intrinsic Trp fluorescence and interaction with hydrophobic probe bis-ANS, whereas mutation R140G decreased both intrinsic fl...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2013.04.014
更新日期:2013-08-01 00:00:00
abstract::NADH cytochrome b5 oxidoreductase (Ncb5or) protects β-cells against oxidative stress and lipotoxicity. The predominant phenotype of lean Ncb5or-null mouse is insulin-dependent diabetes due to β-cell death. This suggests the putative role of NCB5OR polymorphism in human diabetes. Therefore, we aimed to investigate the ...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2013.03.004
更新日期:2013-07-01 00:00:00
abstract::The Nicotiana tabacum Nt-4/1 protein is a plant-specific protein of unknown function. Analysis of bacterially expressed Nt-4/1 protein in vitro revealed that the protein secondary structure is mostly alpha-helical and suggested that it could consist of three structural domains. Earlier studies of At-4/1, the Arabidops...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2013.02.015
更新日期:2013-07-01 00:00:00
abstract::Coumarins are a group of natural compounds widely distributed in plants. Of late, coumarins and their derivatives have grabbed much attention from the pharmacological and pharmaceutical arena due to their broad range of therapeutical qualities. A coumarin derivative 4-methylesculetin (4-ME) has known to possess effect...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2013.02.014
更新日期:2013-06-01 00:00:00
abstract::Azelaic acid (AzA), a C9 linear α,ω-dicarboxylic acid, is found in whole grains namely wheat, rye, barley, oat seeds and sorghum. The study was performed to investigate whether AzA exerts beneficial effect on hepatic key enzymes of carbohydrate metabolism in high fat diet (HFD) induced type 2 diabetic C57BL/6J mice. C...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2013.01.018
更新日期:2013-06-01 00:00:00
abstract::Hemorrhage is the most potent manifestation of envenomation by Vipera ammodytes ammodytes (V. a. ammodytes) venom in man. A detailed description of the venom components contributing to this effect is thus medically very important. We have characterized a novel component, termed here VaH3, as a potently hemorrhagic sna...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2013.01.003
更新日期:2013-06-01 00:00:00
abstract::Poly(ADP-ribosyl)ation is a posttranslational protein modification significant for genomic stability and cell survival in response to DNA damage. Poly(ADP-ribosyl)ation is catalyzed by poly(ADP-ribose)polymerases (PARPs). Among the 17 members of the PARP family, PARP-1 and PARP-2 are described as enzymes whose catalyt...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2013.01.007
更新日期:2013-06-01 00:00:00
abstract::Sodium channel alpha subunit type 1 (SCN1A) is voltage gated ion channel which plays critical role in membrane excitability. A common SCN1A IVS5-91G>A (rs3812718) allele has been attributed to be a possible modifying factor for epilepsy susceptibility and therapeutic response. In the present study, we enrolled 485 epi...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2013.02.006
更新日期:2013-06-01 00:00:00